How Resistant is ‘Treatment-Resistant’ Obsessive-Compulsive Disorder in Youth?

Treatment-resistant obsessive-compulsive disorder (OCD) refers to OCD that persists after trials of at least two evidence-based treatments, typically cognitive behavioral therapy (CBT) incorporating exposure and response prevention and an adequate trial of a selective serotonin reuptake inhibitor (SSRI).

Despite following treatment guidelines, symptoms remain at a clinically significant level, causing distress and impairment in functioning. More intensive or alternative interventions may be required for these refractory cases.

Obsessive-Compulsive Symptoms in Sexual Minorities

The current study suggests that sexual minorities endorse more severe obsessive-compulsive symptoms of unacceptable thoughts related to violence, sex, or religion. Cognitive-behavioral and minority stress frameworks explain why sexual minorities may paradoxically endorse the most socially stigmatized obsessive-compulsive symptoms.