Autonomic Nervous System

Definition, Divisions and Function

By Olivia Guy-Evans, published April 28, 2021

Fact checked by Saul Mcleod, PhD

The autonomic nervous system (ANS) is part of the peripheral nervous system, and is responsible for the control of vital functions such as heart beat, breathing and digestion. It is also involved in the acute stress response where it works with the endocrine system to prepare the body to fight or flight. It can be further subdivided into the sympathetic and parasympathetic divisions.

The ANS transmits information from and to the internal body organs such as the liver and the lungs. It operates automatically, and is generally considered to be outside the realm of voluntary control.

Examples of the types of functions controlled by the ANS are salivating, sweating, changing pupil size, managing heart rate, crying, and secreting hormones.

The ANS therefore differs from the somatic nervous system (another branch of the peripheral nervous system) as this system is associated with controlling voluntary body movements. Although most of the functions of the ANS are automatic, they can however work in conjunction with the somatic nervous system.

The ANS works by receiving information from either external stimuli or the body. The hypothalamus, which is right above the brain stem, receives autonomic regulatory input from the limbic system (a group of structures deep in the brain which are associated with functions such as memory, emotion, and fear). The hypothalamus uses this input to control much of the activity of the ANS.

There are also three key neurotransmitters involved for successful communication within the ANS:

1. Acetylcholine – primarily found within the parasympathetic nervous system, which has an inhibiting effect.
2. Epinephrine – also known as adrenaline, primarily found within the sympathetic nervous system, which has a stimulating effect.
3. Norepinephrine – also known as noradrenaline, primarily found within the sympathetic nervous system, which has a stimulating effect.

Functions

Below is a list of some of the functions of the ANS:

• Mechanism for the fight-or-flight response
• Regulating blood pressure
• Regulating heart rate
• Secretion of bodily fluids such as saliva, sweat, and urine
• Breathing
• Regulating body temperature
• Pupillary responses
• Regulating metabolism

The ANS is important for regulating the body, essential for maintain homeostasis. This means the balance of the body’s conditions and functions necessary for living.

More recently, the ANS is believed to be associated with emotions. Activation of the ANS was found when people responded to positive and negative emotions (Shiota et al., 2011).

Divisions of the ANS

There are three branches to the ANS; the sympathetic nervous system, the parasympathetic nervous system, and the enteric nervous system.

The sympathetic and parasympathetic divisions of the autonomic nervous system have the opposite effects on various systems. The two systems have complementary functions, operating in tandem to maintain the body’s homeostasis

The nerves in the sympathetic nervous system help to prepare the body for something happening within the environment and expend energy. The nerves in the parasympathetic nervous system mostly work by regulating the body’s functions when at rest, controlling mostly ‘quieter’ activities.

Autonomic Dysfunction

Dautonomic dysfunction, or dysautonomia, is a condition in which the autonomic nervous system (ANS) does not function properly.

In developed countries, the most common cause of issues with the ANS result from diabetes (Bishop, 2010). However, other reasons could be due to hereditary reasons, aging, Parkinson’s disease, cancer, or chronic fatigue syndrome. Other reasons could be inflicted onto someone via damage to the head, damage to the neck nerves, alcohol and drug abuse or infections.

If someone believes they may have an issue with their ANS, they could be displaying one or more of the following symptoms:

• Abnormally high or low blood pressure
• Lack of pupillary response
• Severe anxiety or depression
• Digestive issues
• Breathing
• Lack of sweating or too much sweating
• Tachycardia (abnormally fast heart rate)
• Incontinence issues
• Feeling achy, or experiencing pains
• Light-headedness
• Feeling faint or actually fainting

Autonomic neuropathy refers to the damage of autonomic nerves. These are disorders which can affect the sympathetic nerves, parasympathetic nerves, or both.

The features of autonomic neuropathy include having a fixed heart rate, constipation, abnormal sweating, decreased pupil size, and absent or delayed light reflexes (Bankenahally & Krovvidi, 2016).

There are a number of other disorders which can be the result of ANS dysfunction:

• Acute autonomic paralysis – associated with spinal cord injury, resulting in acute and uncontrolled hypertension.
• Multiple system atrophy – a rare condition which causes gradual damage to the nerve cells. Pure autonomic failure – dysfunction of many processes controlled by the ANS.
• Familial dysautonomia – also known as Riley-Day syndrome. This is an inherited condition where the nerve fibers do not function properly so these individuals have trouble feeling pain, temperature, pressure, and positioning their arms and legs.

Autonomic Dysfunction Diagnosis and Treatment

If experiencing the aforementioned symptoms and an individual wants to know whether this is related to their ANS being dysfunctional, there are many tests that can be carried out, depending on the symptom that is being experienced.

For instance, if experiencing abnormal heart rhythms, a doctor may use an electrocardiogram to measure electrical activity within the heart.

Blood pressure monitors can also be used to test whether blood pressure is abnormally high or low. Sweat tests can be used to assess whether the sweat glands are functioning properly.

This involves the use of electrodes to stimulate the glands and measure the sweat volumes produced when presented with a stimulus. Pupillary light reflex tests can also be used to determine how sensitive pupils are to changes in light and whether they respond appropriately or not.

These types of physical examinations are required if someone believes they may have an issue with their ANS. Typically, if there is an issue, this may require a lot of trial and error of many tests to be able to diagnose a condition.

To be able to treat a dysfunctional ANS, again depends on the type of diagnosis given. For example, if the cause of dysfunction is due to diabetes, controlling blood sugars will be the primary treatment. In many cases, treatment of the underlying disease (if applicable) can allow damaged nerves within the ANS to repair and regenerate.

It could be that lifestyle changes are recommended by a doctor in order to treat ANS dysfunction. This could be to exercise more frequently or to modify eating habits or diet, cut down on caffeine, or take vitamin supplements.

Drug therapies have also shown to be effective in helping to treat or manage ANS dysfunction. This can include medications that are used to lower blood pressure and non-steroid anti-inflammatories to help control pain (especially for fibromyalgia).

Similarly, antidepressants and anti-anxiety medications can assist with the symptoms of anxiety and have been shown to help re-balance the ANS.