Parts of the Brain

The brain is the coordinating center of the Central Nervous System (CNS), integrating sensory information to regulate both conscious thought and involuntary survival mechanisms.

It functions by processing inputs from sensory receptors and generating coordinated responses through effectors: muscles and glands.

Structurally, the brain is dominated by the cerebrum, which comprises approximately 85% of its mass.

This region is divided into specialized lobes. These lobes are responsible for “high-order” functions, including cognition, memory, and emotional response.

While the cerebrum handles conscious awareness, deeper structures like the cerebellum, hypothalamus, and medulla oblongata work in tandem to manage motor coordination and homeostasis.

Understanding this neuroanatomy is vital to seeing how localized regions contribute to the overall behavior and physiological stability of the organism.

Parts of the Brain

The brain is composed of the cerebrum, cerebellum, and brainstem (Fig. 1).

Cerebrum

The cerebrum is the largest and most recognizable part of the brain.

It consists of grey matter (the cerebral cortex ) and white matter at the center.

The cerebrum is divided into two hemispheres, the left and right, and contains the lobes of the brain (frontal, temporal, parietal, and occipital lobes).

The cerebrum produces higher functioning roles such as thinking, learning, memory, language, emotion, movement, and perception.

The Cerebellum

The cerebellum is located under the cerebrum and monitors and regulates motor behaviors, especially automatic movements.

The cerebellum helps regulate posture and balance, and has recently been suggested for being involved in learning and attention.

The cerebellum makes up about 11% of brain weight. Even so, it holds far more neurons than the rest of the brain combined.

A large-scale neuron count settled the question. It found the adult brain contains around 86 billion neurons in total. Roughly 69 billion of these, about four-fifths, sit in the cerebellum, compared with only around 16 billion in the cerebral cortex (Herculano-Houzel, 2009).

These figures overturned the long-repeated textbook estimate of 100 billion neurons spread fairly evenly across the brain.

Brainstem

The brainstem is located at the base of the brain.

This area connects the cerebrum and the cerebellum to the spinal cord, acting as a relay station for these areas.

The brainstem regulates automatic functions such as sleep cycles, breathing, body temperature, digestion, coughing, and sneezing.

🧠 Review: Major Brain Regions

1. What are the three main parts of the brain, and what is one function of each?
2. How does the cerebellum support movement and coordination?
3. Which brain region connects to the spinal cord and regulates automatic functions like breathing?

Right Brain vs. Left Brain

The cerebrum is divided into two halves: the right and left hemispheres (Fig. 2).

The left hemisphere controls the right half of the body, and the right hemisphere controls the left half.

The corpus callosum connects the two hemispheres. This thick band of neural fibers is made up of about 200 million axons.

The corpus callosum allows the two hemispheres to communicate and allows information being processed on one side of the brain to be shared with the other.

Hemispheric Lateralization

Hemispheric lateralization is the idea that each hemisphere is responsible for different functions.

Each of these functions is localized to either the right or left side.

The left hemisphere is associated with language functions, such as formulating grammar and vocabulary and containing different language centers (Broca’s and Wernicke’s area).

The right hemisphere is associated with more visuospatial functions such as visualization, depth perception, and spatial navigation.

These left and right functions are the case in most people, especially those who are right-handed.

Lobes of the Brain

Each cerebral hemisphere can be subdivided into four lobes, each associated with different functions.

The four lobes of the brain are the frontal, parietal, temporal, and occipital lobes (Figure 3).

Frontal lobes

The frontal lobes are located at the front of the brain, behind the forehead (Figure 4).

Their main functions are associated with higher cognitive functions, including problem-solving, decision-making, attention, intelligence, and voluntary behaviors.

The frontal lobes contain the motor cortex responsible for planning and coordinating movements.

It also contains the prefrontal cortex, which is responsible for initiating higher-level cognitive functioning, and Broca’s Area, which is essential for language production.

Phineas Gage shows what frontal lobe damage can do. In 1848, an iron rod pierced his frontal lobes in a railway accident.

Gage survived. His personality and judgment changed permanently afterward (Harlow, 1868).

Damage to Broca’s area produces Broca’s aphasia: fluent, grammatical speech is lost, but comprehension stays intact. Broca (1861) first described this in a patient who could understand language but could barely speak.

Temporal lobes

The temporal lobes are located on both sides of the brain, near the temples of the head, hence the name temporal lobes (Figure 5).

The main functions of these lobes include understanding, language, memory acquisition, face recognition, object recognition, perception, and auditory information processing.

There is a temporal lobe in both the left and right hemispheres.

The left temporal lobe, which is usually the most dominant in people, is associated with language, learning, memorizing, forming words, and remembering verbal information.

The left lobe also contains a vital language center known as Wernicke’s area, which is essential for language development.

The right temporal lobe is usually associated with learning and memorizing non-verbal information and determining facial expressions.

Parietal lobes

The parietal lobe is located at the top of the brain, between the frontal and occipital lobes, and above the temporal lobes (Figure 6).

The parietal lobe is essential for integrating information from the body’s senses to allow us to build a coherent picture of the world around us.

These lobes allow us to perceive our bodies through somatosensory information (e.g., through touch, pressure, and temperature). It can also help with visuospatial processing, reading, and number representations (mathematics).

The parietal lobes also contain the somatosensory cortex, which receives and processes sensory information, integrating this into a representational map of the body.

This means it can pinpoint the exact area of the body where a sensation is felt, as well as perceive the weight of objects, shape, and texture.

Occipital lobes

The occipital lobes are located at the back of the brain behind the temporal and parietal lobes and below the occipital bone of the skull (Figure 7).

The occipital lobes receive sensory information from the eyes’ retinas, which is then encoded into different visual data.

Some of the functions of the occipital lobes include being able to assess the size, depth, and distance, determine color information, object and facial recognition, and mapping the visual world.

The occipital lobes also contain the primary visual cortex. It receives sensory information from the retinas and encodes details like location, spatial data, motion, and color.

🧠 Review: Lobes of the Cerebral Cortex

1. Which lobe is responsible for decision-making and voluntary movement?
2. What is the primary function of the occipital lobe?
3. How does the parietal lobe help us perceive touch and spatial awareness?

Cerebral Cortex

The surface of the cerebrum (Figure 8) is called the cerebral cortex. It has a wrinkled appearance, made up of bulges known as gyri and deep furrows known as sulci.

A gyrus (plural: gyri) is a raised fold. Gyri are the bumps and ridges on the cerebral cortex (the outermost layer of the brain).

A sulcus (plural: sulci) is another name for a groove in the cerebral cortex.

The cerebral cortex is primarily constructed of grey matter (neural tissue made up of neurons), with between 14 and 16 billion neurons found here.

The many folds and wrinkles increase surface area. This lets far more neurons fit inside the skull, so the brain can process much larger amounts of information.

Subcortical structures

Beneath the cerebral cortex lie several key subcortical brain regions that play essential roles in emotion, memory, sensory processing, and motor control.

These include the following:

Limbic System

The limbic system is a network of interconnected structures deep within the brain that supports emotional regulation, memory, and motivation.

Key components include the amygdala, which processes emotional responses like fear; the hippocampus, involved in memory formation; and the hypothalamus, which helps regulate basic drives such as hunger and stress.

By linking emotional experience to memory and bodily responses, the limbic system plays a vital role in how we perceive and react to the world.

Amygdala

The amygdala is a brain region deep in the brain that is involved in the processing of emotions and fear learning.

The amygdala is a part of the limbic system, a neural network that mediates emotion and memory (Figure 9).

The amygdala also ties emotional meaning to memories, processes rewards, and helps us make decisions.

This brain region has also been linked with the fight-or-flight response.

Damage here can cause Klüver-Bucy syndrome.

Affected individuals lose their normal fear response and become unusually calm, even around threats (Klüver & Bucy, 1939; Hayman et al., 1998).

Thalamus and Hypothalamus

The thalamus is an egg-shaped mass of grey matter that relays information between the cerebral cortex, brain stem, and other brain regions (Figure 10).

Because of its interactive role in relaying sensory and motor information, the thalamus contributes to many processes, including attention, perception, timing, and movement.

The thalamus is not just a passive relay. It actively gates and coordinates the ongoing activity between cortical areas, making it a hub within brain-wide networks rather than a simple switchboard (Sherman, 2016).

The hypothalamus modulates a range of behavioral and physiological functions.

It controls autonomic functions such as hunger, thirst, body temperature, and sexual activity.

To do this, the hypothalamus integrates information from different brain parts and responds to various stimuli such as light, odor, and stress.

Hippocampus

The hippocampus is a curved-shaped structure in the limbic system associated with learning and memory (Figure 11).

The hippocampus plays a key role in forming memories.

It serves as an early storage system for long-term memory and helps convert them into permanent memory.

The clearest evidence for this comes from patient H.M.

After surgeons removed both his hippocampi to treat severe epilepsy, he lost the ability to form new long-term memories (Scoville & Milner, 1957). His memories from before the surgery stayed intact.

Basal Ganglia

The basal ganglia are a group of structures that regulate the coordination of fine motor movements, balance, and posture alongside the cerebellum.

The basal ganglia are connected to other motor areas and link the thalamus with the motor cortex.

The basal ganglia are also involved in cognitive and emotional behaviors, as well as playing a role in reward and addiction.

Damage to the basal ganglia produces two well-known movement disorders.

In Parkinson’s disease, dopamine-producing neurons in the substantia nigra degenerate. This causes the tremor, rigidity, and slowness (bradykinesia) that define the condition (Ehringer & Hornykiewicz, 1960).

In Huntington’s disease, degeneration of the caudate nucleus and putamen instead produces involuntary, jerky movements.

🧠 Review: Subcortical Structures

1. What role does the hippocampus play in memory?
2. How does the hypothalamus help regulate body functions?
3. Which structure helps process fear and emotional responses?

Ventricles and Cerebrospinal Fluid

Within the brain, there are fluid-filled interconnected cavities called ventricles, which are extensions of the spinal cord.

The ventricles produce cerebrospinal fluid, and also transport and remove it. They do not have one unique function of their own.

Instead, they cushion the brain and help mark the location of other brain regions.

Cerebrospinal fluid is a clear, colorless liquid. It circulates through the brain and spinal cord and cushions the brain within the skull.

If the skull is damaged, this fluid acts as a shock absorber, helping to protect the brain from injury.

Beyond cushioning, cerebrospinal fluid circulates nutrients and chemicals filtered from the blood, and removes waste products from the brain. It is constantly absorbed and replenished by the ventricles.

A disruption or blockage in this cycle can cause cerebrospinal fluid to build up, enlarging the ventricles.

Neurons

Neurons are the nerve cells of the central nervous system that transmit information through electrochemical signals throughout the body.

Neuron Structure and Types

Neurons contain a soma. This cell body is where the axon extends from, the longest part of the neuron, conducting electrical impulses away from the soma.

Dendrites sit at the other end of the neuron. These branch-like structures send and receive information from other neurons.

A myelin sheath, a fatty insulating layer, forms around the axon. It lets nerve impulses travel down the axon quickly.

There are different types of neurons. Sensory neurons transmit sensory information, motor neurons transmit motor information, and relay neurons allow sensory and motor neurons to communicate.

Synaptic Transmission

The communication between neurons is called a synapse. Neurons communicate via synaptic clefts, small gaps between the endings of neurons.

During synaptic transmission, chemicals called neurotransmitters are released from the presynaptic neuron. These chemicals cross the synaptic cleft to reach receptors on the next, postsynaptic neuron.

The message travels on. It influences functions such as behavior and movement, and depending on the neurotransmitter and receptor involved, can excite or inhibit the receiving neuron.

Glial Cells

Glial cells are non-neuronal cells in the central nervous system which work to provide the neurons with nourishment, support, and protection.

Astrocytes

These are star-shaped cells that function to maintain the environment for neuronal signaling by controlling the levels of neurotransmitters surrounding the synapses.

They also work to clean up what is left behind after synaptic transmission, either recycling any leftover neurotransmitters or cleaning up when a neuron dies.

Oligodendrocytes

These types of glial have the appearance of balls with spikes all around them.

They function by wrapping around the axons of neurons to form a protective layer called the myelin sheath.

This is a substance that is rich in fat and provides insulation to the neurons to aid neuronal signaling.

Microglial

Microglial cells have oval bodies and many branches projecting out of them.

The primary function of these cells is to respond to injuries or diseases in the central nervous system.

They respond by clearing away any dead cells or removing any harmful toxins or pathogens that may be present, so they are, therefore, important to the brain’s health.

Ependymal cells

These cells are column-shaped and usually line up together to form a membrane called the ependyma.

The ependyma is a thin membrane lining the spinal cord and ventricles of the brain.

In the ventricles, these cells have small hairlike structures called cilia, which help encourage the flow of cerebrospinal fluid.

🧠Review: Neurons and Glial Cells

1. What are the three main parts of a neuron, and what does each do?
2. What is the function of the myelin sheath?
3. Name two types of glial cells and explain their roles.

Cranial Nerves

There are 12 types of cranial nerves which are linked directly to the brain without having to pass through the spinal cord. These allow sensory information to pass from the organs of the face to the brain:

Mnemonic for Order of Cranial Nerves:

S ome S ay M arry M oney B ut M y B rother S ays B ig B rains M atter M ore

1. Cranial I: Sensory
2. Cranial II: Sensory
3. Cranial III: Motor
4. Cranial IV: Motor
5. Cranial V: Both (sensory & motor)
6. Cranial VI: Motor
7. Cranial VII: Both (sensory & motor)
8. Cranial VIII: Sensory
9. Cranial IX: Both (sensory & motor)
10. Cranial X: Both (sensory & motor)
11. Cranial XI: Motor
12. Cranial XII: Motor

References

Purves, D., Augustine, G., Fitzpatrick, D., Katz, L., LaMantia, A., McNamara, J., & Williams, S. (2001). Neuroscience 2nd edition. sunderland (ma) sinauer associates. Types of Eye Movements and Their Functions.

Mayfield Brain and Spine (n.d.). Anatomy of the Brain. Retrieved July 28, 2021, from: https://mayfieldclinic.com/pe-anatbrain.htm

Robertson, S. (2018, August 23). What is Grey Matter? News Medical Life Sciences. https://www.news-medical.net/health/What-is-Grey-Matter.aspx

Guy-Evans, O. (2021, April 13). Temporal lobe: definition, functions, and location. Simply Psychology. https://www.simplypsychology.org/temporal-lobe.html

Guy-Evans, O. (2021, April 15). Parietal lobe: definition, functions, and location. Simply Psychology. https://www.simplypsychology.org/parietal-lobe.html

Guy-Evans, O. (2021, April 19). Occipital lobe: definition, functions, and location. Simply Psychology. https://www.simplypsychology.org/occipital-lobe.html

Guy-Evans, O. (2021, May 08). Frontal lobe function, location in brain, damage, more. Simply Psychology. https://www.simplypsychology.org/frontal-lobe.html

Guy-Evans, O. (2021, June 09). Gyri and sulci of the brain. Simply Psychology. https://www.simplypsychology.org/gyri-and-sulci-of-the-brain.html

Broca, P. (1861). Remarques sur le siège de la faculté du langage articulé, suivies d’une observation d’aphémie (perte de la parole). Bulletin de la Société Anatomique de Paris, 6, 330–357.

Ehringer, H., & Hornykiewicz, O. (1960). Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. Klinische Wochenschrift, 38, 1236–1239.

Harlow, J. M. (1868). Recovery from the passage of an iron bar through the head. Publications of the Massachusetts Medical Society, 2(3), 327–347.

Hayman, L. A., Rexer, J. L., Pavol, M. A., Strite, D., & Meyers, C. A. (1998). Klüver-Bucy syndrome after bilateral selective damage of amygdala and its cortical connections. The Journal of Neuropsychiatry and Clinical Neurosciences, 10(3), 354–358.

Herculano-Houzel, S. (2009). The human brain in numbers: A linearly scaled-up primate brain. Frontiers in Human Neuroscience, 3, 31.

Klüver, H., & Bucy, P. C. (1939). Preliminary analysis of functions of the temporal lobes in monkeys. Archives of Neurology and Psychiatry, 42(6), 979–1000.

Scoville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 20(1), 11–21.

Sherman, S. M. (2016). Thalamus plays a central role in ongoing cortical functioning. Nature Neuroscience, 19(4), 533–541.